
A Quick Guide to Infuser Chains
Hi everyone! Thanks for playing Pathogenic! It’s always a delight to see everyone coming up with all kinds of crazy combos with their parasites. Since launch, we’ve received…




You are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host's immune system. Conquer a beautiful, procedurally generated world of tiny proportions.
In Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.
To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.
Loot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.
Battle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.
Collect plasmid fragments to permanently upgrade your parasite's plasmid tree between runs. Each parasite will have it's own upgrade tree allowing for a range of builds to suit your preferred playstyle.
Navigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety - each run offers a fresh and challenging gameplay experience.

PathogenicSteam announcement
Hi everyone! Thanks for playing Pathogenic! It’s always a delight to see everyone coming up with all kinds of crazy combos with their parasites. Since launch, we’ve received…
Rob ManuelPost
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PathogenicSteam announcement
Hi Parasites! We're back with a new update! This time the focus is mostly on balancing. We've been combing through all your feedback here on Steam and on our Discord reporting…
PathogenicSteam announcement
Hey Parasites! Thursday July 30 marked the second week since Pathogenic launched and the end of our launch sale. Thanks to all of your support, these two weeks couldn’t have gone…
PathogenicSteam announcement
Hey Parasites! Pathogenic just passed 100k copies sold! Thank you so much for your support that helped us reach this massive milestone in less than a week after launch. Now for…
PathogenicSteam announcement
Hey Parasites! A MASSIVE thanks to all of you for such an incredible launch weekend! Seeing everyone playing our microscopic shooter and giving us so many kind comments and…
DestructoidArticle
A guide on how to defeat the final boss in Pathogenic.
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